abstract：:Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, p...

journal_title：Allergy

authors： Hoffmann PR

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:With the current increasing incidence of allergies worldwide, new treatments showing efficacy and long term safety are needed for chronic conditions such as persistent allergic rhinitis (PER). New generation H1-antihistamines have demonstrated anti-allergic properties, which could possibly enhance their effe...

journal_title：Allergy

authors： Fantin S,Maspero J,Bisbal C,Agache I,Donado E,Borja J,Mola O,Izquierdo I,international Rupatadine study group.

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The house dust mite (HDM) Dermatophagoides pteronyssinus is a major allergen source eliciting allergic asthma. The aim of the study was to identify new important HDM allergens associated with allergic asthma. METHODS:A cDNA coding for a new mite allergen, designated Der p 21, was isolated using immunoglobul...

journal_title：Allergy

authors： Weghofer M,Dall'Antonia Y,Grote M,Stöcklinger A,Kneidinger M,Balic N,Krauth MT,Fernández-Caldas E,Thomas WR,van Hage M,Vieths S,Spitzauer S,Horak F,Svergun DI,Konarev PV,Valent P,Thalhamer J,Keller W,Valenta R,Vrtal

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Nuclear factor kappaB (NF-kappaB) overactivation plays a crucial role in T-helper 2 (Th2)-biased allergic airway inflammation by increased activation and decreased apoptosis of CD4(+) T cells. We have shown that targeted NF-kappaB suppression in dendritic cells by adenoviral gene transfer of a novel mutated ...

journal_title：Allergy

authors： Zhou LF,Zhang MS,Hu AH,Zhu Z,Yin KS

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Retrospective studies provide evidence that rhinitis is associated with more severe asthma. The aim of this study was to evaluate prospectively whether rhinitis is a predictor of increased asthma severity. METHODS:Five hundred and fifty-seven patients with severe asthma were enrolled. During 1 year of follo...

journal_title：Allergy

authors： Ponte EV,Franco R,Nascimento HF,Souza-Machado A,Cunha S,Barreto ML,Naspitz C,Cruz AA

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...

journal_title：Allergy

authors： Hooper R,Calvert J,Thompson RL,Deetlefs ME,Burney P

更新日期：2008-04-01 00:00:00

abstract：:Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H(1)-receptor antagonists have in the treatment of these disorders. However, histamine is clearly not the only mediator involved in the inflammatory cascade. Th...

journal_title：Allergy

authors： Mullol J,Bousquet J,Bachert C,Canonica WG,Gimenez-Arnau A,Kowalski ML,Martí-Guadaño E,Maurer M,Picado C,Scadding G,Van Cauwenberge P

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Although airway hyperresponsiveness (AHR) is a characteristic feature of asthma, it is also frequently present in allergic rhinitis (AR). However, the pathogenesis of AHR is unclear and the roles of cytokines in the airway have not been well established in AR. We sought to compare cytokine mRNA levels in the...

journal_title：Allergy

authors： Sohn SW,Lee HS,Park HW,Chang YS,Kim YK,Cho SH,Kim YY,Min KU

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. OBJECTIVE:To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with...

journal_title：Allergy

authors： Boralevi F,Hubiche T,Léauté-Labrèze C,Saubusse E,Fayon M,Roul S,Maurice-Tison S,Taïeb A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Aspirin, a cyclo-oxygenase (COX)-1 and COX-2 inhibitor, is the antiplatelet drug of choice to prevent serious vascular events. Adverse reactions to aspirin are frequent particularly among patients with asthma, chronic rhinosinusitis and nasal polyps. COX-1 inhibitors but not COX-2 inhibitors precipi...

journal_title：Allergy

authors： Fraj J,Valero A,Vives R,Pérez I,Borja J,Izquierdo I,Picado C

更新日期：2008-01-01 00:00:00

abstract：:The objective was to present a case of periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), summarize the medical literature on PFAPA, review the differential diagnosis and suggest a diagnostic approach to periodic fevers in children. A PubMed search was conducted for all case reports an...

journal_title：Allergy

authors： Lierl M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Signal transducer and activator of transcription 1 (STAT1), an intracellular signal transducer and activator of transcription centrally involved in many inflammatory pathways, was recently suggested to play an important role in allergy related immune responses. AIM:Thus, we investigated the effect of polymo...

journal_title：Allergy

authors： Pinto LA,Steudemann L,Depner M,Klopp N,Illig T,Weiland SK,von Mutius E,Kabesch M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Specific oral tolerance induction (SOTI) seems to be a promising treatment of food allergy. Specific oral tolerance induction and elimination diet were compared with respect to efficacy rate and patterns of clinical reaction. METHODS:Children with challenge proven immunoglobulin E (IgE)-mediated cow's milk ...

journal_title：Allergy

authors： Staden U,Rolinck-Werninghaus C,Brewe F,Wahn U,Niggemann B,Beyer K

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The general understanding is that a blood sample for analysis of immunoglobulin (Ig) E antibodies to an allergen suspected to cause an anaphylaxis cannot be drawn until several weeks after the reaction. As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluat...

journal_title：Allergy

authors： Guttormsen AB,Johansson SG,Oman H,Wilhelmsen V,Nopp A

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2-lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma. OBJECTIVE:We hypothesize...

journal_title：Allergy

authors： Wang TN,Chiang W,Tseng HI,Chu YT,Chen WY,Shih NH,Ko YC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Budesonide/formoterol (Symbicort) Maintenance and Reliever Therapy (SMART) is an effective asthma-management approach that treats symptoms with rapid increases in budesonide/formoterol. The cost-effectiveness of SMART vs higher fixed-dose budesonide/formoterol or salmeterol/fluticasone is unknown. METHODS:T...

journal_title：Allergy

authors： Price D,Wirén A,Kuna P

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Fluticasone furoate is a novel-enhanced affinity glucocorticoid and its long-term safety must be assessed. This study was designed to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR). METHO...

journal_title：Allergy

authors： Rosenblut A,Bardin PG,Muller B,Faris MA,Wu WW,Caldwell MF,Fokkens WJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...

journal_title：Allergy

authors： Hu Y,Matsumoto Y,Dogru M,Okada N,Igarashi A,Fukagawa K,Tsubota K,Fujishima H

更新日期：2007-08-01 00:00:00

abstract：:Anaphylaxis is a growing paediatric clinical emergency that is difficult to diagnose because a consensus definition was lacking until recently. Many European countries have no specific guidelines for anaphylaxis. This position paper prepared by the EAACI Taskforce on Anaphylaxis in Children aims to provide practical g...

journal_title：Allergy

authors： Muraro A,Roberts G,Clark A,Eigenmann PA,Halken S,Lack G,Moneret-Vautrin A,Niggemann B,Rancé F,EAACI Task Force on Anaphylaxis in Children.

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Anaphylaxis is an acute systemic allergic reaction, which can be life-threatening. H(1)-antihistamines are commonly used as an adjuvant therapy in the treatment of anaphylaxis. We sought to assess the benefits and harm of H(1)-antihistamines in the treatment of anaphylaxis. METHODS:We searched the Cochrane ...

journal_title：Allergy

authors： Sheikh A,Ten Broek V,Brown SG,Simons FE

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined. PATIENTS AND METHODS:We evaluated the diagnost...

journal_title：Allergy

authors： Canani RB,Ruotolo S,Auricchio L,Caldore M,Porcaro F,Manguso F,Terrin G,Troncone R

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Little information is available on the clinical efficacy of sublingual immunotherapy (SLIT) using extracts derived from mammalian epithelia. OBJECTIVES:To assess clinical efficacy of cat SLIT based on natural exposure challenge test (NCT). MATERIAL AND METHODS:Fifty cat allergic patients with rhinoconjunct...

journal_title：Allergy

authors： Alvarez-Cuesta E,Berges-Gimeno P,González-Mancebo E,Fernández-Caldas E,Cuesta-Herranz J,Casanovas M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Clinical tools for predicting poor outcomes in asthma patients are lacking. This study investigated the association of asthma control and subsequent severe asthma-related healthcare events in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS:The extent of...

journal_title：Allergy

authors： Sullivan SD,Wenzel SE,Bresnahan BW,Zheng B,Lee JH,Pritchard M,Kamath TV,Weiss ST,TENOR Study Group.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The mechanisms of late asthmatic reactions provoked in atopic asthmatics by allergen-derived T-cell peptide epitopes remain unclear. Previous studies showed no changes in airway eosinophils or mast cell products after peptide challenge. In the present study our aim was to measure calcitonin gene-related pept...

journal_title：Allergy

authors： Kay AB,Ali FR,Heaney LG,Benyahia F,Soh CP,Renz H,Lee TH,Larché M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:We hypothesized that, in south-west Poland, a 'rural' protective effect on atopy and respiratory allergies would be most pronounced among children but that at all ages would be stronger among those with a rural background. METHODS:A cross-sectional survey of the inhabitants (age >5 years, n = 1657) of Sobot...

journal_title：Allergy

authors： Sozanska B,Macneill SJ,Kajderowicz-Kowalik M,Danielewicz H,Wheatley M,Newman Taylor AJ,Boznanski A,Cullinan P

更新日期：2007-04-01 00:00:00

abstract：:Identification and characterization of risk and protective factors for allergy is important for developing strategies for prevention or treatment. The prevalence of allergy is clearly higher in affluent countries than in developing countries like, e.g. Africa. Especially in urban areas of developing countries, allergy...

journal_title：Allergy

authors： van Ree R,Yazdanbakhsh M

更新日期：2007-03-01 00:00:00

abstract：:Specific Immunotherapy for respiratory allergy is used since about one century and there is now solid documentation of its efficacy. Nevertheless, the methods and experimental designs used in clinical trials are quite heterogeneous and there is no unanimously accepted methodological standard. Many studies are planned ...

journal_title：Allergy

authors： Canonica GW,Baena-Cagnani CE,Bousquet J,Bousquet PJ,Lockey RF,Malling HJ,Passalacqua G,Potter P,Valovirta E

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients. METHODS:Baseline pati...

journal_title：Allergy

authors： Sullivan SD,Rasouliyan L,Russo PA,Kamath T,Chipps BE,TENOR Study Group.

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The worldwide increasing incidence of allergic diseases requires the development of new, efficient vaccination strategies, the only curative treatment with a long-lasting effect. Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time. METHODS:We engineered m...

journal_title：Allergy

authors： Crameri R,Flückiger S,Daigle I,Kündig T,Rhyner C

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Up to 10% of the patients in whom suspected betalactam hypersensitivity (HS) has been excluded by skin and challenge tests report suspected allergic reactions during subsequent treatments with the same or very similar betalactams. It has been suggested that the reactions may result from a resensitization ind...

journal_title：Allergy

authors： Ponvert C,Weilenmann C,Wassenberg J,Walecki P,Bourgeois ML,de Blic J,Scheinmann P

更新日期：2007-01-01 00:00:00

abstract：:This update aimed to review the new evidence available to support or refute prior Allergic Rhinitis and its Impact on Asthma (ARIA) statements. A Medline search of publications between 2000 and 2005 was conducted, with articles selected by experts. New evidence supports previous ARIA statements, such as: (i) allergic ...

journal_title：Allergy

authors： Cruz AA,Popov T,Pawankar R,Annesi-Maesano I,Fokkens W,Kemp J,Ohta K,Price D,Bousquet J,ARIA Initiative Scientific Committee.

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Patch testing is the standard clinical procedure to prove contact sensitization. It is a common practice to attach multiple patch tests at the same time. However, synchronous reactions to unrelated allergens may not be completely unassociated. If so, the reaction in a given test field might be influenced by ...

journal_title：Allergy

authors： Brasch J,Geier J,Schnuch A,Uter W,German Contact Dermatitis Research Group (DKG).,Information Network of Departments of Dermatology (IVDK).

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Mannitol-induced bronchoconstriction in subjects with exercise-induced asthma is associated with increased urinary excretion of 9alpha, 11beta-PGF(2), a metabolite of prostaglandin D(2) (PGD(2)) serving as a mast cell marker. It has however been questioned whether or not human mast cells release PGD(2) and l...

journal_title：Allergy

authors： Gulliksson M,Palmberg L,Nilsson G,Ahlstedt S,Kumlin M

更新日期：2006-12-01 00:00:00

abstract：:Sleep is fundamental for physical and mental health as well as daytime performance and represents a crucial aspect in the personal representations of well-being. Sleep disturbances in patients with chronic disorders constitute a factor that contributes to exacerbate symptoms, complicate management, and affect mood and...

journal_title：Allergy

authors： Baiardini I,Braido F,Cauglia S,Canonica GW

更新日期：2006-11-01 00:00:00

abstract：:Endocrine disrupters (EDs) are environmental pollutants of industrial or agricultural origin (e.g. herbicides, fungicides, insecticides, industrial chemicals) that may influence health of wildlife and human. Endocrine-disrupting effect is obtained by mimicking the action of the steroid hormones and has been associated...

journal_title：Allergy

authors： Chalubinski M,Kowalski ML

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Quantitative relationships between immunological reactivity, non-specific bronchial responsiveness and bronchial responsiveness to allergens have scarcely been investigated in occupational asthma. METHODS:We assessed the above relationships in 24 subjects with baker's asthma. The skin endpoint titration to ...

journal_title：Allergy

authors： Quirce S,Fernández-Nieto M,Escudero C,Cuesta J,de Las Heras M,Sastre J

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Two-flow cytometry methods for quantification of degranulated basophil after allergen-specific activation were discussed. The methods are discerned by used membrane receptors--FcepsilonRI or IL-3Ralpha Our goal was to evaluate the diagnostic potential of the methods and to correlate them to allergen-specific...

journal_title：Allergy

authors： Michova A,Abugalia M,Ivanova Ts,Nikolov G,Taskov H,Petrunov B

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY:To investigate the immunol...

journal_title：Allergy

authors： Hanf G,Brachmann I,Kleine-Tebbe J,Seybold J,Kunkel G,Suttorp N,Noga O

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Allergic diseases have become a major public health problem in developed countries; yet, no reliable, safe and consistently effective treatment is available. DNA immunization has been shown to prevent and balance established allergic responses, however, the high dose of conventional DNA vaccines necessary fo...

journal_title：Allergy

authors： Scheiblhofer S,Gabler M,Leitner WW,Bauer R,Zoegg T,Ferreira F,Thalhamer J,Weiss R

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:There has been no study for evaluating the associations of human leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate (TDI)-induced asthma in an Asian population. OBJECTIVE:The aim of this study was to investigate a susceptible or protective marker of HLA class I and II alleles in TDI-in...

journal_title：Allergy

authors： Kim SH,Oh HB,Lee KW,Shin ES,Kim CW,Hong CS,Nahm DH,Park HS

更新日期：2006-07-01 00:00:00